Celery

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Clinical Studies
References


(Apium graveolens)

The applicable parts of celery are the fruit and seed. Sedative and antispasmodic effects of celery seed may be due to d-limonene, volatile oils, flavonoids and other active constituents. Celery has anti-arthritis effects. Another constituent, apigenin, has shown evidence of antiplatelet activity. Standardised to 85% phthalides, celery helps to regulate prostaglandins and promotes alkalinisation as a mild diuretic. This action has anti-inflammatory properties that reduces joint swelling and pain in many arthritic conditions and helps to reduce further joint degeneration. Celery is used to treat arthritis and gout.

 

 

Published Clinical Studiescl top

 1
Combination anti-inflammatory therapy: synergism in rats of NSAIDs/corticosteroids with some herbal/animal products.

Whitehouse MW, Butters DE.

 

Therapeutics Research Unit, Department of Medicine, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia.

A useful function of any complementary medicine is to supplement some of the benefits from other treatment modalities. In rats, extracts from Indian celery seed and the NZ green-lipped mussel are powerful nutraceuticals that (i) amplify the potency of salicylates and prednisone for treating pre-established chronic inflammation (arthritis, fibrosis) and (ii) reduce the steroid's gastrotoxic and lymphopenic side effects. Such combinations might also be useful for treating inflammatory components of (a) osteoarthritis caused by microcrystalline hydroxyapatite (BCP) and (b) pseudo-gout, associated with calcium pyrophosphate crystals; that are usually refractory to monotherapy.

PMID: 15035799 [PubMed]

 

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Referencesre

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. Wichtl MW. Herbal Drugs and Phytopharmaceuticals. Ed. N.M. Bisset. Stuttgart: Medpharm GmbH Scientific Publishers, 1994.
  4. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  5. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  6. FDA. Center for Food Safety and Applied Nutrition, Office of Premarket Approval, EAFUS: A food additive database. Available at: vm.cfsan.fda.gov/~dms/eafus.html.
  7. Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.
  8. Gral N, Beani JC, Bonnot D, et al. [Plasma levels of psoralens after celery ingestion]. [Article in French]. Ann Dermatol Venereol 1993;120:599-603.
  9. Moses, G. Thyroxine interacts with celery seed tablets? Australian Prescriber 2001;24:6-7.
  10. Bauer L, Ebner C, Hirschwehr R, et al. IgE cross-reactivity between birch pollen, mugwort pollen, and celery is due to three distinct cross-reacting allergens: immunoblot investigation of the birch-mugwort-celery syndrome. Clin Exp Allergy 1996;26:1161-70.